bioscience schreef op 3 jun 2016 om 08:42:
Jij hebt geen aandelen meer , dat is duidelijk !
Anders had je dit bericht als eerste geplaatst op de dag .
Tevens opvallend dat ze zo gemakkelijk en met weinig korting geld ophalen . Nu staan er hier uiteraard zeeer weinig aandelen uit . Ik hou ze iig stevig vast .
Wederom mooie ontwikkeling onder .
Published: 07:00 CEST 03-06-2016 /GlobeNewswire /Source: argenx N.V. / : ARGX /ISIN: NL0010832176
argenx announces efficacy and expanded safety data from Phase 1 trial of ARGX-111
Additional preclinical data support potential of ARGX-111 in targeting tumor microenvironment?
?Breda, the Netherlands/Ghent, Belgium – argenx (Euronext Brussels: ARGX), a clinical-stage biopharmaceutical company focused on creating and developing differentiated therapeutic antibodies to treat cancer and severe autoimmune diseases, today announced data published in conjunction with the American Society of Clinical Oncology (ASCO) 2016 Annual Meeting (Chicago, USA) presenting efficacy and safety data from its ARGX-111 Phase 1 expansion study in patients with MET amplified tumors. The data confirm ARGX-111 to have a favorable safety profile and to continue to show signs of anti-tumor activity. The abstract can be accessed here.
In addition, data from preclinical studies demonstrate depletion of MET-positive myeloid-derived suppressor cells (MDSCs) by ARGX-111. These data provide an exciting new perspective for therapeutic intervention in MET cancer biology in targeting both the tumor cells and the tumor microenvironment.
ARGX-111 is a Met-targeting human monoclonal SIMPLE Antibody™ that modulates all known mechanisms of action of the receptor. ARGX-111 benefits from POTELLIGENT®-enhanced Antibody Dependent Cellular Cytotoxicity (ADCC), which drives the immune system to destroy
c-MET positive cells of the primary tumor and the circulating tumor cells that are responsible for metastasis; and from NHance®, which is thought to drive tissue penetration. This unique combination results in a potentially best-in-class drug candidate for c-Met therapies. ARGX-111 is tested in a Phase 1 safety expansion cohort in MET-amplified patients.
argenx combines the diversity of the llama immune system with antibody engineering to advance a clinical pipeline to treat patients with cancer and autoimmune diseases. Our platforms allow us to unlock novel and complex targets and develop antibody-based drugs designed for greater efficacy and longer duration of effect. The strength of our team, our deep understanding of the biology, and our committed collaborations with industry leaders contribute to the success of our journey.www.argenx.com