Mrs Elizabeth Goodwin, can you confirm this as typo?
Of course, on top of that, the oral, taking a pill a day versus injection or IV, is also a big advantage. So, I think longer-term, first line is the way to go.
However, we don't (Fout Reuter i.m.o) need to have a lot of safety data to be able to convince doctors to change their view of not starting treatment with the TNFs.