[0009] In the embodiments of the invention, the C1 esterase inhibitor can be a modified C1 esterase inhibitor as compared to human plasma-derived C1 esterase inhibitor. It can be modified to modulate the plasma half-life of the C1 esterase inhibitor. A specific modified C1 esterase inhibitor is conjugated to enhance the plasma half-life. An exemplary conjugated C1 esterase inhibitor to enhance half-life is a conjugated C1 esterase inhibitor according to WO2017/176798, which is herein incorporated by reference, such as a polysialic acid (PSA)-conjugated C1 esterase inhibitor, more preferably a polyethylene glycol (PEG)-conjugated C1 esterase inhibitor. The modification of the C1 esterase inhibitor can be a modified carbohydrate structure as compared to human plasma-derived C1 esterase inhibitor. A specific modified C1 esterase inhibitor has a reduced level of terminal sialic acid residues as compared to plasma derived C1 esterase inhibitor, wherein said reduced level of terminal sialic acid residues may result in a reduction of plasma half-life to less than 6 hours. A specific C1 esterase inhibitor having a reduced level of terminal sialic acid residues as compared to plasma derived C1 esterase inhibitor is a C1 esterase inhibitor according to WO01/57079, WO2004/100982 and WO2007/073186 which are herein incorporated by reference. The compound according to the invention can be administered as such and can be administered comprised in a pharmaceutical composition. The pharmaceutical composition can comprise a pharmaceutically accepted excipient and/or can comprise a further pharmaceutical compound. The compound according to the invention may be administered by any means known to the person skilled in the art, such as but not limited, to intravenous, transdermal and subcutaneous administration. Intravenous administration is extensively described in WO01/57079, WO2004/100982 and WO2007/073186. Subcutaneous administration is preferably performed as in WO2014/145519, U.S. Pat. No. 9,616,111B2 and EP2968434B1, which are herein incorporated by reference.
[0010] In the embodiments of the invention, the compound according to the invention can be administered to the subject at least once a month, or at least once a week. The compound according to the invention can be administered at least once, twice, three or four times a month, at least once, twice, three, four, five, six or seven times a week or can be administered, every other day, daily, or twice a day.
[0011] When the compound according to the invention is a C1 esterase inhibitor, the compound can be administered in a dose ranging from 25 units/kg body weight to 100 units/kg body weight per administration, preferably ranging from 50 units/kg body weight to 100 units/kg body weight per administration. Per administration the dose can be 25 units/kg body weight, 50 units/kg body weight, 100 units/kg body weight. The total dose per administration can be 1000 units, 1400 units, 1500 units, 2000 units, 2100 units, 2800 units, 3000 units, 3500 units, 4000 units, 4200 units, 4500 units, 4900 units, 5000 units, 5600 units, 6000 units, 6300 units, 7000 units, 7500 units, 8000 units, 8400 units or 9000 units C1 inhibitor.
[0012] In the embodiments of the invention, the subject can be a pregnant mammal, preferably a pregnant human.
[0013] In the embodiments of the invention, the subject suffering from pre-eclampsia can be suffering from early-onset pre-eclampsia (<34 weeks gestational age) or from late-onset pre-eclampsia (>34 weeks gestational age).
[0014] The diagnosis of pre-eclampsia or of a risk of pre-eclampsia can be made by any means and assay known to the person skilled in the art. The diagnosis may e.g. be made by assessing whether there is occurrence of hypertension en proteinuria. The diagnosis can be made by measurement of P-type inositolphosphoglycans (P-type IPG) in a bodily fluid, such as in blood or urine.