Many infectious and noninfectious causes of relative bradycardia in febrile patients have been described (e.g. typhoid fever),
but the pathogenesis of this phenomenon is still unknown. Direct
pathogen effects on the sinoatrial node and effects of inflammatory
cytokines are among the proposed mechanisms [4]. Interestingly,
interleukin 6 (IL-6) is the cytokine reported to exhibit the strongest
correlation with depressed heart rate variability, which in turn may
predict relative bradycardia [4]. On the other hand, IL-6 appears to
play also an important role in the cytokine storm caused by SARSCoV-2.
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As reported on 21 April 2020, following treatment with RUCONEST®, fever resolved in four of the five patients within 48 hours, and laboratory markers of inflammation decreased significantly (CRP, IL-6).
..with depressed heart rate variability..vandaar ook de uitbreiding naar onderzoek hart..??