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Zei zoeken naar een vaccine

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[verwijderd] 13 april 2020 12:48
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DRAFT landscape of COVID-19 candidate vaccines – 11 April 20203 candidate vaccines in clinical evaluation

Platform
Type of candidate vaccine
Developer
Coronavirus target
Current stage of clinical evaluation/regulatory status- Coronavirus candidate
Same platform for non-Coronavirus candidates
Non- Replicating Viral Vector

Adenovirus Type 5 Vector
CanSino Biological Inc./Beijing Institute of Biotechnology
COVID-19
Phase 2
ChiCTR2000031781
Phase 1
ChiCTR2000030906

Ebola
DNA
DNA plasmid vaccine Electroporation device
Inovio Pharmaceuticals
COVID-19
Phase 1
NCT04336410

Lassa, Nipah HIV Filovirus HPV
Cancer indications Zika
Hepatitis B
RNA
LNP- encapsulated mRNA
Moderna/NIAID
COVID-19
Phase 1
NCT04283461
multiple candidates
[verwijderd] 13 april 2020 12:50
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Platform
Type of candidate vaccine
Developer
Coronavirus target
Current stage of clinical evaluation/regulatory status- Coronavirus candidate

Same platform for non-Coronavirus candidates

DNA
DNA with electroporation
Karolinska Institute / Cobra Biologics (OPENCORONA Project)
COVID-19
Pre-Clinical

DNA
DNA plasmid vaccine
Osaka University/ AnGes/ Takara Bio
COVID-19
Pre-Clinical
DNA
DNA
Takis/Applied DNA Sciences/Evvivax

COVID-19

Pre-Clinical
DNA
Plasmid DNA, Needle-Free Delivery
Immunomic Therapeutics, Inc./EpiVax, Inc./PharmaJet, Inc.
COVID-19
Pre-Clinical
SARS
[verwijderd] 13 april 2020 12:51
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DNA
DNA plasmid vaccine
Zydus Cadila
COVID-19
Pre-Clinical
Inactivated

Inactivated + alum

Sinovac
COVID-19

Pre-Clinical
SARS
Inactivated
Inactivated
Beijing Institute of Biological Products/Wuhan Institute of Biological Products
COVID-19
Pre-Clinical

Inactivated

TBD
Osaka University/ BIKEN/ NIBIOHN

COVID-19
Pre-Clinical

Live Attenuated Virus
Deoptimized live attenuated vaccines
Codagenix/Serum Institute of India
COVID-19
Pre-Clinical
HAV, InfA, ZIKV, FMD, SIV, RSV, DENV
Non- Replicating Viral Vector
ChAdOx1
University of Oxford
COVID-19
Phase 1/2 (not yet recruiting) NCT04324606


MERS, influenza, TB, Chikungunya, Zika, MenB, plague

Non- Replicating Viral Vector
MVA encoded VLP
GeoVax/BravoVax
COVID-19
Pre-Clinical
LASV, EBOV, MARV, HIV
Non- Replicating Viral Vector
Ad26 (alone or with MVA boost)
Janssen Pharmaceutical Companies
COVID-19
Pre-Clinical

Ebola, HIV, RSV
Non- replicating viral vector
MVA-S encoded
DZIF – German Center for Infection Research
COVID-19

Pre-clinical

Many
Non- Replicating Viral Vector
adenovirus- based NasoVAX expressing SARS2-CoV spike protein
Altimmune
COVID-19
Pre-Clinical
influenza
Non- Replicating Viral Vector
Ad5 S (GREVAXTM platform)
Greffex
COVID-19
Pre-Clinical
MERS
[verwijderd] 13 april 2020 12:52
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Non- Replicating Viral Vector
Oral Vaccine platform
Vaxart
COVID-19
Pre-Clinical
InfA, CHIKV, LASV, NORV; EBOV, RVF, HBV, VEE
Non- Replicating Viral Vector

MVA expressing structural proteins

Centro Nacional Biotecnología (CNB-CSIC), Spain
COVID-19

Pre-Clinical
HIV, HCV, chikungunya, Ebola, zika, malaria, leishmania
Protein Subunit
Capsid-like Particle
AdaptVac (PREVENT-nCoV consortium)
COVID-19
Pre-Clinical

Protein Subunit

Drosophila S2 insect cell expression system VLPs
ExpreS2ion

COVID-19
Pre-Clinical

Protein Subunit
Peptide antigens formulated in lipid nanoparticle formulation
IMV Inc
COVID-19
Pre-Clinical
Protein Subunit
S protein
WRAIR/USAMRIID
COVID-19
Pre-Clinical

Protein Subunit
S protein +Adjuvant
National Institute of Infectious Disease, Japan
COVID-19
Pre-Clinical

Influenza

Protein Subunit
VLP- recombinant protein + Adjuvant
Osaka University/ BIKEN/ National Institutes of Biomedical Innovation, Japan
COVID-19
Pre-Clinical
Protein Subunit
Native like Trimeric subunit Spike Protein vaccine
Clover Biopharmaceuticals Inc./GSK/Dynavax
COVID-19
Pre-Clinical

HIV, REV Influenza
Protein Subunit
microneedle arrays S1 subunit
Univ. of Pittsburgh
COVID-19
Pre-Clinical
MERS
Protein Subunit
Peptide
Vaxil Bio

COVID-19

Pre-Clinical
[verwijderd] 13 april 2020 12:53
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Protein Subunit
Adjuvanted protein subunit (RBD)
Biological E Ltd
COVID-19
Pre-Clinical
Protein Subunit

Peptide

Flow Pharma Inc
COVID-19

Pre-Clinical
Ebola, Marburg, HIV, Zika, Influenza, HPV therapeutic vaccine, BreastCA vaccine
Protein Subunit
S protein
AJ Vaccines
COVID-19
Pre-Clinical

Protein Subunit

Ii-Key peptide
Generex/EpiVax

COVID-19
Pre-Clinical
Influenza, HIV, SARS-CoV

Protein Subunit
S protein
EpiVax/Univ. of Georgia
COVID-19
Pre-Clinical
H7N9
Protein Subunit
S protein (baculovirus production)
Sanofi Pasteur
COVID-19
Pre-Clinical

Influenza, SARS-CoV

Protein Subunit
VLP- recombinant protein nanoparticle vaccine + Matrix M
Novavax
COVID-19
Pre-Clinical
RSV; CCHF, HPV, VZV, EBOV
Protein Subunit
gp-96 backbone
Heat Biologics/Univ. Of Miami
COVID-19
Pre-Clinical

NSCLC, HIV, malaria, Zika
Protein Subunit
Molecular clamp stabilized Spike protein
University of Queensland/GSK/Dynavax
COVID-19
Pre-Clinical

Nipah, influenza, Ebola, Lassa
Protein Subunit
S1 or RBD protein
Baylor College of Medicine
COVID-19
Pre-Clinical
SARS
Protein Subunit
Subunit protein, plant produced
iBio/CC-Pharming

COVID-19

Pre-Clinical
[verwijderd] 13 april 2020 12:54
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Protein Subunit
Recombinant protein, nanoparticles (based on S- protein and other epitopes)
Saint-Petersburg scientific research institute of vaccines and serums
COVID-19
Pre-Clinical
Protein Subunit
COVID-19 XWG-03 truncated S (spike) proteins
Innovax/Xiamen Univ./GSK
COVID-19
Pre-Clinical
HPV
Protein Subunit
Adjuvanted microsphere peptide
VIDO-InterVac, University of Saskatchewan
COVID-19
Pre-Clinical
Protein Subunit

Synthetic Long Peptide Vaccine candidate for S and M proteins

OncoGen
COVID-19

Pre-Clinical
Replicating Viral Vector
Measles Vector
Zydus Cadila
COVID-19
Pre-Clinical

Replicating Viral Vector
Measles Vector
Institute Pasteur/Themis/Univ. of Pittsburg Center for Vaccine Research
COVID-19
Pre-Clinical
West nile, chik, Ebola, Lassa, Zika
Live attenuated virus
Measles Virus (S, N targets)
DZIF – German Center for Infection Research
COVID-19
Pre-clinical

Zika, H7N9, CHIKV

Replicating Viral Vector
Horsepox vector expressing S protein
Tonix Pharma/Southern Research
COVID-19
Pre-Clinical
Smallpox, monkeypox

Replicating Viral Vector
Live viral vectored vaccine based on attenuated influenza virus backbone (intranasal)
BiOCAD and IEM
COVID-19
Pre-Clinical
Replicating Viral Vector
Influenza vector expressing RBD
University of Hong Kong

COVID-19

Pre-Clinical
Replicating Viral Vector
VSV vector expressing S protein
IAVI/Batavia
COVID-19
Pre-Clinical
Ebola, Marburg, Lassa
[verwijderd] 13 april 2020 12:55
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RNA
LNP- encapsulated mRNA cocktail encoding VLP
Fudan University/ Shanghai JiaoTong University/RNACure Biopharma
COVID-19
Pre-Clinical
RNA

LNP- encapsulated mRNA encoding RBD

Fudan University/ Shanghai JiaoTong University/RNACure Biopharma
COVID-19

Pre-Clinical
RNA
Replicating Defective SARS- CoV-2 derived RNAs
Centro Nacional Biotecnología (CNB-CSIC), Spain
COVID-19
Pre-Clinical

RNA

LNP- encapsulated mRNA
University of Tokyo/ Daiichi-Sankyo

COVID-19
Pre-Clinical
MERS

RNA
Liposome- encapsulated mRNA
BIOCAD
COVID-19
Pre-Clinical
RNA
mRNA
China CDC/Tongji University/Stermina
COVID-19
Pre-Clinical

RNA
mRNA
Arcturus/Duke-NUS
COVID-19
Pre-Clinical

multiple candidates
RNA
mRNA
BioNTech/Fosun Pharma/Pfizer
COVID-19
Pre-Clinical

RNA
saRNA
Imperial College London
COVID-19
Pre-Clinical

EBOV; LASV, MARV, Inf (H7N9), RABV

RNA
mRNA
Curevac
COVID-19
Pre-Clinical
RABV, LASV, YFV; MERS, InfA, ZIKV, DengV, NIPV

VLP
Virus-like particle, based on RBD displayed on virus-like particles
Saiba GmbH
COVID-19
Pre-Clinical
VLP
Plant-derived VLP
Medicago Inc.
COVID-19

Pre-Clinical
Flu, Rotavirus, Norovirus, West Nile virus, Cancer
VLP
ADDomerTM multiepitope display
Imophoron Ltd and Bristol University’s Max Planck Centre
COVID-19
Pre-Clinical
Unknown
Unknown
ReiThera

COVID-19
Pre-Clinical
Unknown
Unknown
BioNet Asia

COVID-19
Pre-Clinical
Unknown
Unknown
ImmunoPrecise

COVID-19

Pre-Clinical
Unknown
Unknown
MIGAL Galilee Research Institute
COVID-19
Pre-Clinical
[verwijderd] 13 april 2020 12:57
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Unknown
Unknown
Doherty Institute
COVID-19
Pre-Clinical
Unknown
Unknown
Tulane University
COVID-19
Pre-Clinical

DISCLAIMER:
These landscape documents have been prepared by the World Health Organization (WHO) for information purposes only concerning the 2019-2020 global of the novel coronavirus. Inclusion of any particular product or entity in any of these landscape documents does not constitute, and shall not be deemed or construed as, any approval or endorsement by WHO of such product or entity (or any of its businesses or activities). While WHO takes reasonable steps to verify the accuracy of the information presented in these landscape documents, WHO does not make any (and hereby disclaims all) representations and warranties regarding the accuracy, completeness, fitness for a particular purpose (including any of the aforementioned
purposes), quality, safety, efficacy, merchantability and/or non-infringement of any information provided in these landscape documents and/or of any of the products referenced therein. WHO also disclaims any and all liability or responsibility whatsoever for any death, disability, injury, suffering, loss, damage or other prejudice of any kind that may arise from or in connection with the procurement, distribution or use of any product included in any of these landscape documents.
[verwijderd] 13 april 2020 13:11
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Is kiadis ook van de partij ?
[verwijderd] 13 april 2020 13:17
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quote:

Twin schreef op 13 april 2020 13:11:

Is kiadis ook van de partij ?
Zover ik kan zien niet.
Ook de buurtjes van Pharming niet.
[verwijderd] 13 april 2020 13:33
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Dank u break up voor uw antwoord
[verwijderd] 13 april 2020 14:18
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We gaan het zien
[verwijderd] 13 april 2020 15:43
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quote:

Twin schreef op 13 april 2020 13:33:

Dank u break up voor uw antwoord
Graag gedaan overigens zal bij de buren de CEO zijn hart overslaan mocht het gebruikt worden, begrijp mij niet verkeerd, dat zou de prijs van Ruconest om zeep hebben geholpen.
Want als medicatie tegen Corona daar zit deze niet op te wachten is mijn overtuiging.
Maar hij kan denk ik gerust zijn.
[verwijderd] 13 april 2020 21:27
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Ok
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