Tom3 schreef op 7 juni 2018 08:17:
Deze melding kreeg ik gisteren binnen via SA: de respondent vond de CF scores maar mager. Was dat de reden van de dip gisteren?
ePoster talk on June 7th for the European Cystic Fibrosis Conference. Get the app.
Results: YKL-40 and HE-4 serum assays were successfully established and distinguished healthy from CF cohorts in the qualification study. Baseline concentrations of YKL-40 and HE-4 across PQ-010-001 subjects were not significantly different from the pilot CF cohort, but significantly increased compared to the healthy cohort, and were comparable with ranges reported in literature. Furthermore, the panel of sputum inflammatory markers was successfully measured.
Conclusion: YKL-40 and HE-4 biomarkers are elevated in serum of CF patients. A trend towards decreased serum analyte concentrations was observed in some patients receiving QR-010, but overall, response variability was high. The sputum inflammatory markers did not significantly differ between QR-010 and placebo groups, but further evaluation is currently ongoing.